ABSTRACT
Background: The most prevalent metabolic condi?on, type 2 diabetes mellitus, is characterized by persistent hyperglycemia caused by abnormali?es in insulin produc?on, insulin ac?on, or both. Iron, a transi?onal metal, has been demonstrated to play a key role in the pathophysiology of Type 2 Diabetes Mellitus, with a bidirec?onal link in which iron influences glucose metabolism, which in turn influences the iron metabolic pathways. The current study aimed to es?mate the iron profile in Type 2 diabetes mellitus cases. Methods: This cross-sec?onal study was done in the Department of Biochemistry, Prathima Ins?tute of Medical Sciences, Naganoor, Karimnagar. A total of n=100 cases of type II diabetes mellitus were included in the study and age and sex-matched healthy controls were also included in the study. Laboratory inves?ga?ons included Fas?ng Blood glucose, Serum ferri?n, Total iron-binding capacity, serum iron, and serum transferrin satura?on. Results: The fas?ng blood glucose was found to be significantly higher in the diabetes mellitus cases. The serum ferri?n mean values were 105.32 µgm/dl. In the controls, the range of ferri?n levels was 145 µgm/dl. The serum ferri?n levels were found to be significantly reduced in the study cases as compared to the controls. Similarly, the total iron-binding capacity (TIBC) of the cases was found to be significantly increased as compared to the controls. The serum transferrin levels were also found to be elevated in the study cases as compared to the controls. Conclusion: Iron is closely related to the development of diabetes mellitus. Elevated iron and ferri?n levels are risk factors for diabetes and can lead to a variety of problems. Conversely in chronic diabe?cs, there is a tendency to develop iron deficiency anemia and other nutri?onal deficiency anemias as observed by the results of the current study. As a result, iron profile evalua?on can be a valuable output of the expected inves?ga?ons on diabetes and related problems.